Papers Archive

晨会

共 36 条 · 每页 10 条 · 第 1 / 4 页

01

Tumour assembloids recapitulate tumour–CAF–T cell crosstalk in renal cancer

Eunjee Kim, Minyong Kang, Jang Hee Han, Juhee Lee, Yunhee Kim, Chang Wook Jeong, HyeSun Lee, Hyun Je Kim, Kunyoo Shin

六例患者来源肾癌组装体中，肿瘤WNT2B经CAF的LRP6–activin A维持干样CD8⁺ T细胞；这一联系影响模型对PD-1阻断的反应。

 02

STING reprogramming by estrogen promotes neutrophil extracellular trap formation and sex-biased resistance to ADC therapy

Jingrui Yan, Tianxing Zhou, Shangheng Shi, Guohua Mao, Jingbo Xu, Yu Zhang, Yaqi Zhang, Huizhi Sun, Yifei Wang, Xiuchao Wang, Chongbiao Huang, Rui Liu, Deqing Hu, Shengyu Yang, Jun Yu, Yukuan Feng, Yongjie Xie, Bin Wang, Jihui Hao

胰腺癌等临床前模型中，雌激素通过肿瘤STING–NF-κB–CXCL1信号促进NET形成，限制ADC接触靶点；抑制NET可改善药效。

 03

Osteoclasts intercept meningeal lymphatic paths for dural metastasis

Rui Zeng, Jiaxu Zhao, Haibao Peng, Jiadong Ma, Shuyi Hua, Youming Zeng, Xiaohui Li, Yang Huang, Cheng Li, Jiahui Yang, Hongru Chen, Xue Feng, Qiangqiang Zhang, Liang Chen, Yudan Chi

小鼠硬脑膜转移中，破骨细胞来源ANG2参与脑膜淋巴引流障碍，靶向这一环节可改善CD8⁺ T细胞相关的抗肿瘤效应。

 04

Postprandial lipid metabolism durably enhances T cell immunity

Alok Kumar, Dayana B. Rivadeneira, Isha Mehta, Bingxian Xie, Rachel Cumberland, Supriya K. Joshi, Jitendra S. Kanshana, William G. Gunn, Victoria Dean, Angelina Parise, Kristin Morder, Erica S. Myers, Steven J. Mullett, Richard T. Cattley, Stacy L. Gelhaus, Abigail E. Overacre-Delgoffe, Jishnu Das, William F. Hawse, Alison B. Kohan, Greg M. Delgoffe

健康供者样本与小鼠实验显示，激活时的餐后脂质环境可增强T细胞代谢、扩增及过继治疗模型中的抗肿瘤效应。

 05

Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial

Simon P Bach, David Sebag-Montefiore, Victoria Homer, Alexandra Gilbert, Ane Appelt, Ian Geh, Geerard L Beets, Jacobus Burger, Eva Angenete, Gunnar Baatrup, Karen-Lise Garm Spindler, Karin Haustermans, Fabian Holman, Ellen M Kerkhof, Emily Lam, Stephan Korsgen, Anna Martling, Albert Wolthuis, Issam Al-Najami, Pehr Lind, Femke P Peters, Mark Teo, Nicholas P West, Simon Gates, Corrie A M Marijnen, Johannes H W de Wilt, STAR-TREC Collaborative

STAR-TREC的12个月分析中，长程放化疗后的TME-free生存估计高于短程放疗，30个月主要终点仍待报告。

 06

Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial

Myriam Chalabi, Lauren D W van den Dungen, Peter G M de Gooyer, Sara Balduzzi, Arend G J Aalbers, Emile D Kerver, Cecile Grootscholten, Simone Dokter, Johanne G Bloemen, Eddy R Hendriks, Tjeerd S Aukema, Steven J Oosterling, Wieke H M Verbeek, Emile E Voest, Niels F M Kok, Marnix H Geukes Foppen, Regina G Beets-Tan, Antony Tin, Adham Jurdi, Ton N Schumacher, Monique E van Leerdam, José G van den Berg, John B A G Haanen

dMMR结肠癌NICHE-2长期随访显示，111名符合方案患者在短程纳武利尤单抗、伊匹木单抗及手术后，3年DFS与5年OS估计均为100%。

 07

Ecotypes of triple-negative breast cancer in response to chemotherapy

Yan, Yun, Lin, Yiyun, Kumar, Tapsi, Bai, Shanshan, Thennavan, Aatish, Li, Jianzhuo, Sei, Emi, Tran, Tuan, Hu, Min, Rao, Mitchell, Tang, Chenling, He, Siyuan, Casasent, Anna, Ravenberg, Elizabeth, Rauch, Gaiane Margishvili, Clayborn, Alyson R., Tripathy, Debu, Thompson, Alastair, Lim, Bora, Huo, Lei, Moulder, Stacy, Yam, Clinton, Navin, Nicholas

治疗前单细胞与空间分析将TNBC分解为四种肿瘤内在分型、13种癌细胞元程序和八种生态型，揭示巨噬细胞状态与化疗应答的关联。

 08

Modular in vivo antibody–ADC click to reverse drug resistance in tumours

Cristina Simó, Alexander C. Vanover, Ricardo D’Oliveira Albanus, Sandeep Surendra Panikar, Shayla Shmuel, Alex Benton, Jader Giraldo-Guzman, José M. Luna, Yifei Xu, Na-Keysha Berry, Nai Keltee, Jingxia Liu, Farrokh Dehdashti, Patrícia M. R. Pereira

体内点击连接使抗体与ADC形成复合物，在不同HER2表达的小鼠肿瘤模型中改善递送及部分治疗终点。

 09

Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial

Line Schmidt Tarpgaard, Laurids Østergaard Poulsen, Ismail Gögenur, Tobias Freyberg Justesen, Søren Rafael Rafaelsen, Nadia Øgaard, Christina Demuth, Claus Lindbjerg Andersen, Lise Ventzel, Pernille Øhlenschläger Larsen, Anne Ramlov, Ken Ljungmann, Michael Bødker Lauritzen, Laura Vittrup Diness, Jakob Lykke, Vinicius Araújo Barbosa de Lima, Søren Kjær, Søren Salomon, Per Vadgaard Andersen, Per Pfeiffer

单臂Ⅱ期试验的16例dMMR直肠癌患者，经一或两个周期双免疫治疗后均达到临床完全缓解。

 10

PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity

van Krimpen, Anneloes, Huang, Julie, Eterman, Mike, Gerretsen, Vivian, Umetani, Michihisa, Janssen, Josephine C., van Nimwegen, Menno, Rozendaal, Nina, van den Bosch, Thierry P. P., Jiang, Xinguo, Logronio, Kathryn, Liu, Angela Z., Liu, Yun-Ru, Nagasaki, Yuki, Murakami, Makoto, Onrust-Van Schoonhoven, Anne, Leliveld, Asabi, Vadgama, Disha, Langeveld, Hedwig, van Wijck, Rogier, Bindels, Eric, von der Thüsen, Jan, Mooyaart, Antien, van Maldegem, Febe, Brenis, Claudia M., Verwaerde, Stijn, Hendriks, Rudi W., Lambrecht, Bart N., Grünhagen, Dirk J., Verhoef, Cornelis, Aerts, Joachim G. J. V., Lee, Li-Fen, Lu, Kan V., Stadhouders, Ralph, Dammeijer, Floris

人淋巴结空间分析结合多种小鼠模型，将PLA2G2D定位为限制早期抗肿瘤T细胞扩增、可与PD-1联合阻断的候选检查点。