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Esophageal Cancer

Shao-Hua Xie, Elizabeth Smyth, Jesper Lagergren

综述鳞癌与腺癌的风险、筛查和治疗，区分食管、胃及胃食管交界部的试验证据。

Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization

Rafal Hanc, Robin Demuynck, Dmitri V. Krysko

作者提出STING相关炎症与LTβR介导组织化的两阶段模型，完整因果链仍待验证。

Neoadjuvant Botensilimab/Balstilimab for localized mismatch repair proficient and deficient colon cancer: Results of the NEST phase 2 clinical trial

Manish A. Shah, Erika Hissong, Mehraneh D. Jafari, Pashtoon Murtaza Kasi, Maider Astorkia, Sahrish Khan, Casey Owens, Zhengming Chen, Heather Yeo, Fabio Socciarelli, Sandipto Sarkar, Alana Nguyen, Despina Siolas, Allyson Ocean, Kelly Garrett, Lea Lowenfeld, Alessio Pigazzi, Preethi Guniganti, Sanjay Patel, Doron Betel, Manuel Hidalgo

单臂Ⅱ期NEST中，22个pMMR肿瘤有9个达到主要病理缓解。

Building and regenerating intestines by manipulating intestinal stem cells

Calvin J. Kuo, Sarah Blutt, Mark Donowitz, Mary K. Estes, Chandan Guha, Ophir D. Klein, Linheng Li, Joyce C. Niland, António J. M. Santos, Ramesh A. Shivdasani, Jason R. Spence, Carol J. Swanson, Timothy C. Wang, Kelley S. Yan, Nicholas C. Zachos, Michael A. Helmrath

综述肠干细胞来源、再生生态位及细胞替代策略，转化效果仍依赖损伤模型和功能验证。

Beyond cold to hot: oncolytic virotherapy as the next cornerstone of immuno-oncology

William Jia, Ronghua Zhao, Howard L. Kaufman, Robert L. Martuza

文章讨论溶瘤病毒的免疫启动、载荷和联合策略；已有临床结果并不一致。

Long non-coding RNAs in colorectal cancer: shaping the tumour microenvironment and advancing precision oncology

M. Bartolini, F. Battaglin, S. Soni, S. Algaze, K. Ashouri, L. Torres-Gonzalez, P. Mittal, U. Shah, W. Zhang, J. Millstein, A. Puccini, H.-J. Lenz

综述lncRNA介导的细胞通讯、免疫调节和耐药机制，多数证据仍处于临床前阶段。