晨会
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Tumour assembloids recapitulate tumour–CAF–T cell crosstalk in renal cancer
Eunjee Kim, Minyong Kang, Jang Hee Han, Juhee Lee, Yunhee Kim, Chang Wook Jeong, HyeSun Lee, Hyun Je Kim, Kunyoo Shin
六例患者来源肾癌组装体中，肿瘤WNT2B经CAF的LRP6–activin A维持干样CD8⁺ T细胞；这一联系影响模型对PD-1阻断的反应。
022026-11-04 · 晨会STING reprogramming by estrogen promotes neutrophil extracellular trap formation and sex-biased resistance to ADC therapy
Jingrui Yan, Tianxing Zhou, Shangheng Shi, Guohua Mao, Jingbo Xu, Yu Zhang, Yaqi Zhang, Huizhi Sun, Yifei Wang, Xiuchao Wang, Chongbiao Huang, Rui Liu, Deqing Hu, Shengyu Yang, Jun Yu, Yukuan Feng, Yongjie Xie, Bin Wang, Jihui Hao
胰腺癌等临床前模型中，雌激素通过肿瘤STING–NF-κB–CXCL1信号促进NET形成，限制ADC接触靶点；抑制NET可改善药效。
032026-11-03 · 晨会Osteoclasts intercept meningeal lymphatic paths for dural metastasis
Rui Zeng, Jiaxu Zhao, Haibao Peng, Jiadong Ma, Shuyi Hua, Youming Zeng, Xiaohui Li, Yang Huang, Cheng Li, Jiahui Yang, Hongru Chen, Xue Feng, Qiangqiang Zhang, Liang Chen, Yudan Chi
小鼠硬脑膜转移中，破骨细胞来源ANG2参与脑膜淋巴引流障碍，靶向这一环节可改善CD8⁺ T细胞相关的抗肿瘤效应。
042026-11-02 · 晨会Postprandial lipid metabolism durably enhances T cell immunity
Alok Kumar, Dayana B. Rivadeneira, Isha Mehta, Bingxian Xie, Rachel Cumberland, Supriya K. Joshi, Jitendra S. Kanshana, William G. Gunn, Victoria Dean, Angelina Parise, Kristin Morder, Erica S. Myers, Steven J. Mullett, Richard T. Cattley, Stacy L. Gelhaus, Abigail E. Overacre-Delgoffe, Jishnu Das, William F. Hawse, Alison B. Kohan, Greg M. Delgoffe
健康供者样本与小鼠实验显示，激活时的餐后脂质环境可增强T细胞代谢、扩增及过继治疗模型中的抗肿瘤效应。
052026-10-29 · 晨会Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial
Simon P Bach, David Sebag-Montefiore, Victoria Homer, Alexandra Gilbert, Ane Appelt, Ian Geh, Geerard L Beets, Jacobus Burger, Eva Angenete, Gunnar Baatrup, Karen-Lise Garm Spindler, Karin Haustermans, Fabian Holman, Ellen M Kerkhof, Emily Lam, Stephan Korsgen, Anna Martling, Albert Wolthuis, Issam Al-Najami, Pehr Lind, Femke P Peters, Mark Teo, Nicholas P West, Simon Gates, Corrie A M Marijnen, Johannes H W de Wilt, STAR-TREC Collaborative
STAR-TREC的12个月分析中，长程放化疗后的TME-free生存估计高于短程放疗，30个月主要终点仍待报告。
062026-10-28 · 晨会Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial
Myriam Chalabi, Lauren D W van den Dungen, Peter G M de Gooyer, Sara Balduzzi, Arend G J Aalbers, Emile D Kerver, Cecile Grootscholten, Simone Dokter, Johanne G Bloemen, Eddy R Hendriks, Tjeerd S Aukema, Steven J Oosterling, Wieke H M Verbeek, Emile E Voest, Niels F M Kok, Marnix H Geukes Foppen, Regina G Beets-Tan, Antony Tin, Adham Jurdi, Ton N Schumacher, Monique E van Leerdam, José G van den Berg, John B A G Haanen
dMMR结肠癌NICHE-2长期随访显示，111名符合方案患者在短程纳武利尤单抗、伊匹木单抗及手术后，3年DFS与5年OS估计均为100%。
072026-10-27 · 晨会Ecotypes of triple-negative breast cancer in response to chemotherapy
Yan, Yun, Lin, Yiyun, Kumar, Tapsi, Bai, Shanshan, Thennavan, Aatish, Li, Jianzhuo, Sei, Emi, Tran, Tuan, Hu, Min, Rao, Mitchell, Tang, Chenling, He, Siyuan, Casasent, Anna, Ravenberg, Elizabeth, Rauch, Gaiane Margishvili, Clayborn, Alyson R., Tripathy, Debu, Thompson, Alastair, Lim, Bora, Huo, Lei, Moulder, Stacy, Yam, Clinton, Navin, Nicholas
治疗前单细胞与空间分析将TNBC分解为四种肿瘤内在分型、13种癌细胞元程序和八种生态型，揭示巨噬细胞状态与化疗应答的关联。
082026-10-26 · 晨会Modular in vivo antibody–ADC click to reverse drug resistance in tumours
Cristina Simó, Alexander C. Vanover, Ricardo D’Oliveira Albanus, Sandeep Surendra Panikar, Shayla Shmuel, Alex Benton, Jader Giraldo-Guzman, José M. Luna, Yifei Xu, Na-Keysha Berry, Nai Keltee, Jingxia Liu, Farrokh Dehdashti, Patrícia M. R. Pereira
体内点击连接使抗体与ADC形成复合物，在不同HER2表达的小鼠肿瘤模型中改善递送及部分治疗终点。
092026-10-23 · 晨会Effect of one or two cycles of dual immunotherapy with nivolumab and ipilimumab in patients with mismatch repair-deficient rectal cancer (RESET-R): interim results from a multicentre, single-arm, phase 2 trial
Line Schmidt Tarpgaard, Laurids Østergaard Poulsen, Ismail Gögenur, Tobias Freyberg Justesen, Søren Rafael Rafaelsen, Nadia Øgaard, Christina Demuth, Claus Lindbjerg Andersen, Lise Ventzel, Pernille Øhlenschläger Larsen, Anne Ramlov, Ken Ljungmann, Michael Bødker Lauritzen, Laura Vittrup Diness, Jakob Lykke, Vinicius Araújo Barbosa de Lima, Søren Kjær, Søren Salomon, Per Vadgaard Andersen, Per Pfeiffer
单臂Ⅱ期试验的16例dMMR直肠癌患者，经一或两个周期双免疫治疗后均达到临床完全缓解。
102026-10-22 · 晨会PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
van Krimpen, Anneloes, Huang, Julie, Eterman, Mike, Gerretsen, Vivian, Umetani, Michihisa, Janssen, Josephine C., van Nimwegen, Menno, Rozendaal, Nina, van den Bosch, Thierry P. P., Jiang, Xinguo, Logronio, Kathryn, Liu, Angela Z., Liu, Yun-Ru, Nagasaki, Yuki, Murakami, Makoto, Onrust-Van Schoonhoven, Anne, Leliveld, Asabi, Vadgama, Disha, Langeveld, Hedwig, van Wijck, Rogier, Bindels, Eric, von der Thüsen, Jan, Mooyaart, Antien, van Maldegem, Febe, Brenis, Claudia M., Verwaerde, Stijn, Hendriks, Rudi W., Lambrecht, Bart N., Grünhagen, Dirk J., Verhoef, Cornelis, Aerts, Joachim G. J. V., Lee, Li-Fen, Lu, Kan V., Stadhouders, Ralph, Dammeijer, Floris
人淋巴结空间分析结合多种小鼠模型，将PLA2G2D定位为限制早期抗肿瘤T细胞扩增、可与PD-1联合阻断的候选检查点。
112026-10-21 · 晨会Pharmacologic Inhibition of PMS2 Induces MMR Deficiency and Response to Immune Checkpoint Blockade
Julian Blagg, Philippe Riou, Alexia Hervieu, Eleonora Piumatti, Maria T. Rodriguez-Plata, Paolo Battuello, Adam Peall, Vito Amodio, Pietro Paolo Vitiello, Daniel J.H. Nightingale, Ruzica Bago, Paige Tongue, Tessa Slater, Kalpesh Parmar, Pradip Patel, Javier Rodríguez González, David E. Clark, Gareth W. Langley, Charles Nichols, Alba Guarné, Paul C.M. Winship, Matthew Baker, Martin Drysdale, Giovanni Germano, Alberto Bardelli
共价PMS2抑制剂NP1867使长期体外培养的鼠源肿瘤细胞积累MMR缺陷相关改变，植入小鼠后对抗PD-1更敏感。
122026-10-20 · 晨会Aspirin after curative-intent treatment of colorectal cancer liver metastases (ASAC): a multicentre, phase 3, randomised, double-blind, placebo-controlled trial
Sheraz Yaqub, Morten Valberg, Bjørn Atle Bjørnbeth, Jon-Helge Angelsen, Kristoffer Watten Brudvik, Ina Andrassy Eilertsen, Richard Fristedt, Claus Wilki Fristrup, Stefan Gilg, Oskar Hemmingsson, Bengt Isaksson, Ingebjørg Soterud Juel, Anders Riegels Knudsen, Peter Nørgaard Larsen, Kim Erlend Mortensen, Inge Christoffer Olsen, Per Sandström, Oddvar Mathias Sandvik, Ernesto Sparrelid, Helena Taflin, Ragnhild A Lothe, Kjetil Taskén, ASAC Study Group
ASACⅢ期试验中，肝转移根治性治疗后使用160 mg阿司匹林未改善DFS，并观察到OS与安全性的不利结果。
132026-10-19 · 晨会Werner helicase inhibitor for advanced microsatellite instability solid tumors: a phase 1 trial
Timothy A. Yap, Elisa Fontana, Natalie Cook, Marwan Fakih, Oliver Bechter, Erica S. Tsang, Emiliano Calvo, Kristoffer S. Rohrberg, Javier Ros, Ignacio Matos, John H. Strickler, Malaka Ameratunga, Meredith Pelster, Adam Sharp, Jaspreet Grewal, Susanna Ulahannan, Rajesh Belani, Matthew P. Patricelli, Sophia M. Blake, David Dejardin, Stephen Fowler, Christina Godfried Sie, Astrid Heller, Nina Henkel, Michael Hettich, Angelika Lahr, David Lamparter, Charlotte Lane, Ting Liu, Hélène Meistermann, Christophe Meille, Neil Parrott, Sotirios K. Sotiriou, Denise Reeves, Barbara Romagnoli, Piergiorgio Pettazzoni, Daniel Waterkamp, Matthias Wittwer, Yali Fu, Sophie Postel-Vinay
首次人体Ⅰ期试验中，WRN抑制剂在多线治疗后的MSI实体瘤中显示以疾病稳定为主的活性。
142026-10-16 · 晨会A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion
Chiara Falcomatà, Maximilian M. Schaefer, Bhavya Singh, Divya Chhamalwan, Alexander Tepper, Sebastian R. Nielsen, Hunter T. Potak, Maxime Dhainaut, Gurkan Mollaoglu, Matthew D. Park, Miriam Merad, Alessia Baccarini, Brian D. Brown
空间功能筛选显示，胰腺癌中少数serpin阳性细胞可建立富含巨噬细胞的局部生态位，影响邻近细胞的免疫逃逸。
152026-10-14 · 晨会Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program
Swagata Goswami, Qiming Zhang, Abdullah Burak Yildiz, Upasana Das Adhikari, Akhouri Kishore Raghawan, Manon Bulliard, Sabhyata Sedhain, Odai Darawshi, Cigdem Elif Celik, Feyza Cansiz, Constantin P. Krempe, Jonas Rösler, Gabriele Allies, Sven W. Meckelmann, Chiashin Chi, Felix-Levin Hormann, Sven Heiles, Joseph Sedlak, Wesley Grace, George Eng, Ethan Reich, Chiara Alquati, Kevin J. Williams, Benjamin J. Read, Edrees H. Rashan, Zhixin Li, Anup Jnawali, Jose A. Ortiz, Chesta Jain, Charles A. Whittaker, Osman H. Yilmaz, Vikram Deshpande, Oliver J. Schmitz, Albert Sickmann, Autumn G. York, Douglas S. Kwon, Ulf Neumann, Maria Fedorova, Matthew G. Vander Heiden, Besim Ogretmen, Nilay S. Sethi, Alpaslan Tasdogan, Ömer H. Yilmaz
小鼠和患者来源类器官模型显示，神经酰胺合成通过PP2A–YAP驱动再生样细胞状态，增强CRC肝转移能力。
162026-10-13 · 晨会Targeted therapy in advanced BRAF-mutated colorectal cancer: systematic review and network meta-analysis
Bao-Dong Qin, Xiao-Dong Jiao, Zhan Wang, Ke Liu, Yan Ling, Ying Wu, Yuan-Sheng Zang
系统综述与网络荟萃分析比较BRAF突变晚期CRC的靶向组合，并区分一线与后线证据。
172026-10-12 · 晨会Prior therapy defines mutation profiles in childhood cancer at relapse
Mehdi Layeghifard, Marcos Díaz-Gay, Erik N. Bergstrom, Mathepan J. Mahendralingam, Nicholas Light, Sasha Blay, Joshua O. Nash, Nathaniel D. Anderson, Jessica N. Au, Scott Davidson, Pedro L. Ballester, Timmy Wen, Syed Kashif Daud, Lisa-Monique Edward, S. M. Ashiqul Islam, Azhar Khandekar, Burçak Otlu, Ledia Brunga, Rawan Hammad, Shimaa Nassif, Nirav H. Thacker, Tara Feltham, Noemi A. Fuentes-Bolanos, Marie Wong-Erasmus, Max F. Levine, Katherine E. Miller, Neerav N. Shukla, Michael D. Kinnaman, Dominik Glodzik, Carol Portwine, Sabrina Millson, Alexandra P. Zorzi, Mariam Mikhail, Conrad V. Fernandez, Laura Wheaton, Gunes Gundem, Andrew L. Kung, Uri Tabori, Chelsea Mayoh, Elli Papaemmanuil, Mark J. Cowley, David Malkin, Anita Villani, Ludmil B. Alexandrov, Adam Shlien
611份儿童肿瘤样本显示，铂类相关突变特征的检出与取样时间、突变数量及后续治疗反应有关。
182026-10-10 · 晨会CD4+ T cells impair tumor growth via IL-3 and TNF-dependent vascular damage
Qiaoshi Lian, Jia Nie, Jatinder Singh, Qiang Chen, Jennifer Matta, Waipan Chan, Mariah Balmaceno-Criss, Melanie S. Vacchio, Weiming Yu, Alexander D. Clark, Elijah Edmondson, Michael C. Kelly, Ronald N. Germain, Rémy Bosselut
小鼠研究中，CD4 T细胞通过IL-3激活髓系细胞，以TNF依赖的血管损伤抑制肿瘤。
192026-10-09 · 晨会Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Xiaocui Lu, Xiuyun Wang, Zheng Yang, Xusheng Wang, Lin Wang, Chunhui Xu, I-Chung Lo, Chenlu Geng, Lin Wang, Yisheng Pu, Keyu Zhang, Ziqiang Zhu, Lanxin Ye, Jiayuan Huang, Xiaofan Wei, Fang Bai, Yanan Zhu, Xiaobing Qian, Hao Dou, Hexiu Su, Yong Cang
HuR分子胶降解剂在BRAF突变结直肠癌模型中诱导外显子18跳读，并增强MAPK通路联合抑制。
202026-10-08 · 晨会First-Line Retlirafusp Alfa Plus Chemotherapy for Human Epidermal Growth Factor Receptor 2–Negative Gastric or Gastroesophageal Junction Adenocarcinoma: A Randomized, Double-Blind, Phase III Study (RELIGHT)
Zhi Peng, Jufeng Wang, Yanqiao Zhang, Hongli Li, Qun Zhao, Xiaodong Zhu, Shaozhong Wei, Yan Chen, Wenhui Yang, Jun Yao, Mingjun Zhang, Lin Xie, Xizhi Zhang, Ping Zhao, Changlu Hu, Jingdong Zhang, Kangsheng Gu, Jun Bai, Yigui Chen, Zhongtao Zhang, Jun Zhang, Junsheng Wang, Zuoxing Niu, Yueyin Pan, Zhenyang Liu, Yanhong Deng, Zhigao Wang, Wenliang Wang, Hongxia Han, Lin Shen
RELIGHTⅢ期试验显示，retlirafusp alfa联合CAPOX延长总体及PD-L1 CPS≥5人群生存，CPS<1亚组出现不利信号。
212026-09-30 · 晨会Prognostic genome and transcriptome signatures in colorectal cancers
Luís Nunes, Fuqiang Li, Meizhen Wu, Tian Luo, Klara Hammarström, Emma Torell, Ingrid Ljuslinder, Artur Mezheyeuski, Per-Henrik Edqvist, Anna Löfgren-Burström, Carl Zingmark, Sofia Edin, Chatarina Larsson, Lucy Mathot, Erik Osterman, Emerik Osterlund, Viktor Ljungström, Inês Neves, Nicole Yacoub, Unnur Guðnadóttir, Helgi Birgisson, Malin Enblad, Fredrik Ponten, Richard Palmqvist, Xun Xu, Mathias Uhlén, Kui Wu, Bengt Glimelius, Cong Lin, Tobias Sjöblom
1,063例结直肠癌的全基因组与转录组分析提出五类CRPS分型，并比较其分子特征与生存关联。
222026-09-29 · 晨会Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy
Anne-Laure Mallard de La Varende, Ai-Ling Tian, Simon Thomas, Imran Lahmar, Meriem Messaoudene, Sijing Li, Omar Motiño, Hortense Guillaume-dit-Taunière, Valerio Iebba, Yoan Hurtado, Thao-Nguyen Pham, Cassandra Thélémaque, Miguel Araujo-Voces, Deborah Suissa, Pierre Ly, Ella Reich, Giacomo Vitali, Bryan Thierry Arlunno, Sylvere Durand, Fanny Aprahamian, Marion Leduc, Sabrina Forveille, Oliver Kepp, Carlos de la Calle-Fabregat, Angela Schippers, Norbert Wagner, Pierre-Edouard Fournier, Kenya Honda, Federica Marmorino, Chiara Cremolini, Saman Maleki Vareki, John G. Lenehan, Aurélien Marabelle, François-Xavier Danlos, Margaux Deligne, Caroline Truntzer, François Ghiringhelli, Anne H. Ree, Paula A. Bousquet, Sebastian Meltzer, Florent Ginhoux, Deklan Rummel, Yousi Fu, Robert A. Quinn, Carolina Alves Costa Silva, Roberto Iacovelli, Chiara Ciccarese, Serena Porcari, Arielle Elkrief, Bertrand Routy, Gianluca Ianiro, Lisa Derosa, Guido Kroemer, Marine Fidelle, Laurence Zitvogel
小鼠实验连接胆汁酸变化与免疫治疗抵抗，患者队列显示γGT升高与较差预后相关。
232026-09-28 · 晨会Programming the immunological properties of mRNA vaccines for cancer
Annette Wu, Seong Dong Jeong, Benjamin R. Schrank, Betty Y. S. Kim, Padmanee Sharma, Wen Jiang
从先天感知、抗原呈递、适应性记忆和训练免疫四条轴，讨论mRNA癌症疫苗的设计与证据。
242026-09-24 · 晨会Metastasis enables immunogenicity through migrasome-mediated antigen release
Dong Jiang, Jinzhao He, Renxiang Xie, Minghui Shi, Siyuan Liu, Haohao Jia, Bingjie Yang, Xiaojie Ruan, Xiaoyu Tao, Yuhan Xiang, Yining Chen, Lin Jiao, Xiaoyu Feng, Li Yu
小鼠研究显示，转移癌细胞释放的迁移体可递送肿瘤抗原，经抗原呈递细胞激活CD8⁺ T细胞并限制转移。
252026-09-23 · 晨会A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy
Zeda Zhang, Yu-Jui Ho, Xin Fang, Minseo Kim, Marguerite Li, Wei Luan, Clemens Hinterleitner, Sascha Haubner, Friederike Kogel, Edwin C. Pratt, Elif Ozcelik, José Reyes, Qingwen Jiang, Vincent W. Yang, Yu-Jung Chen, Tao Wang, Haijiao Liu, Haonan Hu, Xueqian Zhuang, Jin Park, Stella V. Paffenholz, Kevin Chen, Qing Chang, Amanda Kulick, Jing Zhang, Eric Chan, Eric Rosiek, Ning Fan, Riley A. Williams, Adam C. Wang, Samuel Freeman, Sha Tian, Gertrude Gunset, Andreina Garcia Angus, Nicolas Lecomte, Selma Yeni Yildirim, Emily Ali, Michelle Wu, Ileana C. Miranda, Cristina R. Antonescu, Olca Basturk, Zeynep Tarcan, Natasha Rekhtman, Christina Wilson, Merve Basar, Jennifer L. Sauter, Hikmat A. Al-Ahmadie, Samuel Singer, Christine Iacobuzio-Donahue, Charles Rudin, Elisa de Stanchina, Karuna Ganesh, Paul B. Romesser, Britta Weigelt, Dan Dongeun Huh, Josef Leibold, Judith Feucht, Ignacio Vázquez-García, Matthew J. Bott, Dmitriy Zamarin, Sohrab P. Shah, Jason S. Lewis, Corina Amor, Dana Pe’er, Jorge Mansilla-Soto, Aveline Filliol, Michel Sadelain, Scott W. Lowe
临床前研究显示uPAR CAR T细胞可同时攻击肿瘤与基质，并与诱导衰老样状态的治疗联合。
262026-09-22 · 晨会Efficacy of Perioperative Pembrolizumab in Mismatch Repair Deficient/Microsatellite Unstable Localized Colorectal Cancers: Results of the Phase II Trial IMHOTEP
Christelle de la Fouchardière, Aziz Zaanan, Aymeric de Montfort, Romain Cohen, Samuel Le Sourd, David Tougeron, Emilie Soularue, Olivier Dubreuil, Nicolas Williet, Emmanuelle Samalin-Scalzi, Guillaume Piessen, Vincent Hautefeuille, Marine Jary, Meher Ben Abdelghani, Ludovic Evesque, Philippe Rochigneux, Ellen Blanc, David Pérol, Frederic Bibeau, Clélia Coutzac
72例可评估患者中38例达到ypT0N0，接受一或两疗程术前帕博利珠单抗。
272026-09-21 · 晨会Spatial multi-omics landscape of colorectal cancer macro- and micrometastases
Yang Liu, Akshaya S. Jadhav, Yuwen Pan, Jianlong Liao, Isha Khanduri, Yunhe Liu, Riham Katkhuda, Wei Lu, Kyung Serk Cho, Zhimin Tong, Tieling Zhou, Kangyu Lin, Baohua Sun, Mei Jiang, Sharia D. Hernandez, Idania Carolina Lubo Julio, Patrick Brennan, Guangsheng Pei, Kai Yu, Yibo Dai, Tian Chu, Fuduan Peng, Khaja Khan, Saxon Rodriguez, Ling Xia, Youming Guo, Alicia Mejia, Sean W. Barnes, Ou Shi, Shreeya Indulkar, Alaa M.T. Mohamed, Natalie Wall Fowlkes, Timothy Newhook, Yun Shin Chun, Van K. Morris, David Menter, Dadi Jiang, John Paul Shen, Ryan Sun, Jean-Nicolas Vauthey, Ruoyan Li, Humam Kadara, Luisa M. Solis Soto, Scott Kopetz, Linghua Wang, Dipen Maru
空间多组学揭示微转移灶的克隆与免疫特征，并提出与复发相关的六基因特征。
282026-09-20 · 晨会MATTERHORN: Perioperative durvalumab plus FLOT (2025 & 2026)
Yelena Y Janjigian, Salah-Eddin Al-Batran, Zev A Wainberg, Kei Muro, Daniela Molena, Eric Van Cutsem, Woo Jin Hyung, Lucjan Wyrwicz, Do-Youn Oh, Takeshi Omori, Markus Moehler, Arinilda C Bragagnoli, Gabriel Garbaos, Moishe Liberman, María Luisa Limón Mirón, Elizabeth C Smyth, Lin-Yang Cheng, Scott H Robbins, Nicola Valeri, Ioannis Xynos, Josep Tabernero
同一试验的两次报告：2025年EFS与pCR改善，2026年最终总生存分析达到预设统计标准。
292026-09-17 · 晨会Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy
Lysanne Desharnais, Anikka Swaby, Meriem Messaoudene, Samuel Doré, Miranda W. Yu, Benoit Fiset, Valérie Breton, Mayra Ponce, Yongjia Hu, Liam Wilson, Mark Sorin, Ye Wang, Ken Dewar, Michael Pollak, Arielle Elkrief, Bertrand Routy, Logan A. Walsh, Daniela F. Quail
小鼠实验显示约氏乳杆菌的作用依赖饮食条件，人体结果仍为探索性线索。
302026-09-16 · 晨会Lean adipocyte oxylipin signaling restrains breast cancer through ferroptosis
Meghan C. Curtin, Abigail E. Jackson, Mark D. Lee, Elisabeth A. Brown, J. Alan Maschek, David H. Lum, James E. Cox, Alana L. Welm, Keren I. Hilgendorf
临床前实验支持9S-HODE诱导乳腺癌细胞铁死亡，脂滴形成可在所测细胞中提供保护。
312026-09-15 · 晨会Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC
Yiming Peng-Winkler, Xiao-Zheng Liu, Sanne M. L. Verheul, Charlotte Girondel, Sebastian Igelmann, Sara Marie Rotter, Michail Doukas, Ming Liu, Anke Vandekeere, Mélanie Planque, Juan Fernández-García, Sébastien Tabariès, Marta Buetas-Arcas, Sandra Martínez-Martín, Florian Döbbe, Margherita Demicco, Ines Vermeire, Janine Theile, Johannes Ceuppens, Jonas Haesevoets, Emma Tobarra-López, Dorien Broekaert, Johannes Georg Bode, Tom Luedde, Peter Vermeulen, Daniele V. F. Tauriello, Raquel Perez-Lopez, Steve Stegen, Laura Soucek, Tiago De Oliveira, Lena-Christin Conradi, Peter M. Siegel, Cornelis Verhoef, Sarah-Maria Fendt
模型研究支持MYC–脯氨酸–胶原轴促进替代型肝转移，MYC抑制的临床分层价值待验证。
322026-09-14 · 晨会Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer
YaTing Wen, LingJie Tang, WenWen Duan, QingFei Ren, YangYue Ni, ShiYang Chen, Jun Chen, Lei Yang, Huan Wang, Yuan Chen, YunZhe Zheng, XingChao Pan, Hui Du, MengWen Huang, An Zeng, Zhaocai Zhou, ZhiGang Zhang, HongBin Ji, GaoXiang Ge, Yi Arial Zeng, Wei Zhang, ShiHui Wang, JianJun Cheng, Sheng Wang, JianFeng Chen
小鼠研究显示，激活肠胶质细胞5-HT₂A受体可增强CD8⁺ T细胞反应及抗PD-1作用。
332026-09-10 · 晨会Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer: The ORCHESTRA Randomized Clinical Trial
Elske C. Gootjes, Lotte Bakkerus, Anviti A. Adhin, Barbara M. Zonderhuis, Kathelijn S. Versteeg, Jurriaan B. Tuynman, Martijn R. Meijerink, Cornelis J. A. Haasbeek, Johannes H. W. de Wilt, Dirk J. Grunhagen, Ewoud J. Smit, John M. Primrose, John Bridgewater, Esther van Meerten, Jan-Willem B. de Groot, Mathijs P. Hendriks, Esther Oomen-de Hoop, Tineke E. Buffart, Cornelis Verhoef, Henk M. W. Verheul
化疗联合减瘤未证实总生存获益，严重不良事件更多；研究对象为多器官转移患者。
342026-09-09 · 晨会Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS/BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial
Yu Sunakawa, Manabu Shiozawa, Takanori Watanabe, Hirofumi Ota, Hisateru Yasui, Taichi Yabuno, Mitsuyoshi Tei, Mitsugu Kochi, Dai Manaka, Hisatsugu Ohori, Tatsuro Yamaguchi, Tamotsu Sagawa, Masahito Kotaka, Yutaro Kubota, Takashi Sekikawa, Masato Nakamura, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii, Akihito Tsuji
总体人群未见显著生存差异；左半RAS/BRAF野生型亚组的PFS结果属探索性，OS未达显著。
352026-09-08 · 晨会Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers
Julian R. Buissant des Amorie, Joris H. Hageman, Sascha R. Brunner, Suzanne E. M. van der Horst, Maria C. Puschhof, Arne van Hoeck, Inge van Lierop, Sjors Middelkamp, Lisa van der Schee, Sven van Kempen, Folkert Morsink, Robin Geene, Sander Mertens, David S. Cavigelli, Ingrid Verlaan-Klink, Lianne J. Kraaier, Jorieke Salij, Renate Bezemer, Onno Kranenburg, Miangela M. Laclé, Leon M. G. Moons, Hugo J. G. Snippert
早期肿瘤侵袭前沿出现胎儿样细胞状态，共培养实验支持局部微环境参与诱导。
362026-09-07 · 晨会ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer
Qingwen Jiang, Manisha S. Raghavan, Aileen M. Rodriguez, Morgan Lallo, Cyrus L. Tam, Saskia Hartner, Britney Forsyth, Ahmed Mahmoud, Fabian Zincke, Huiyong Zhao, Andrew Moorman, Sasha Balkaran, Kathleen Luckett, Jura Pintar, Yevgeniy Romin, Eric Chan, Anthony Santella, Bernadette Mödl, Farheen Shah, Ilyes Baali, Michael G. Kharas, Elisa de Stanchina, Nil Urganci, Jinru Shia, Dana Pe’er, Francisco Sanchez-Vega, Richard Koche, Quaid Morris, Joseph M. Chan, Karuna Ganesh
ZFP36L2参与应激RNA清除；缺失影响再生与早期转移定植，幸存癌细胞仍可沿其他路径生长。
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