Papers Archive

晨会

共 36 条 · 每页 10 条 · 第 4 / 4 页

31

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC

Yiming Peng-Winkler, Xiao-Zheng Liu, Sanne M. L. Verheul, Charlotte Girondel, Sebastian Igelmann, Sara Marie Rotter, Michail Doukas, Ming Liu, Anke Vandekeere, Mélanie Planque, Juan Fernández-García, Sébastien Tabariès, Marta Buetas-Arcas, Sandra Martínez-Martín, Florian Döbbe, Margherita Demicco, Ines Vermeire, Janine Theile, Johannes Ceuppens, Jonas Haesevoets, Emma Tobarra-López, Dorien Broekaert, Johannes Georg Bode, Tom Luedde, Peter Vermeulen, Daniele V. F. Tauriello, Raquel Perez-Lopez, Steve Stegen, Laura Soucek, Tiago De Oliveira, Lena-Christin Conradi, Peter M. Siegel, Cornelis Verhoef, Sarah-Maria Fendt

模型研究支持MYC–脯氨酸–胶原轴促进替代型肝转移，MYC抑制的临床分层价值待验证。

 32

Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer

YaTing Wen, LingJie Tang, WenWen Duan, QingFei Ren, YangYue Ni, ShiYang Chen, Jun Chen, Lei Yang, Huan Wang, Yuan Chen, YunZhe Zheng, XingChao Pan, Hui Du, MengWen Huang, An Zeng, Zhaocai Zhou, ZhiGang Zhang, HongBin Ji, GaoXiang Ge, Yi Arial Zeng, Wei Zhang, ShiHui Wang, JianJun Cheng, Sheng Wang, JianFeng Chen

小鼠研究显示，激活肠胶质细胞5-HT₂A受体可增强CD8⁺ T细胞反应及抗PD-1作用。

 33

Tumor Debulking in Combination With Chemotherapy in Multiorgan Metastatic Colorectal Cancer: The ORCHESTRA Randomized Clinical Trial

Elske C. Gootjes, Lotte Bakkerus, Anviti A. Adhin, Barbara M. Zonderhuis, Kathelijn S. Versteeg, Jurriaan B. Tuynman, Martijn R. Meijerink, Cornelis J. A. Haasbeek, Johannes H. W. de Wilt, Dirk J. Grunhagen, Ewoud J. Smit, John M. Primrose, John Bridgewater, Esther van Meerten, Jan-Willem B. de Groot, Mathijs P. Hendriks, Esther Oomen-de Hoop, Tineke E. Buffart, Cornelis Verhoef, Henk M. W. Verheul

化疗联合减瘤未证实总生存获益，严重不良事件更多；研究对象为多器官转移患者。

 34

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS/BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

Yu Sunakawa, Manabu Shiozawa, Takanori Watanabe, Hirofumi Ota, Hisateru Yasui, Taichi Yabuno, Mitsuyoshi Tei, Mitsugu Kochi, Dai Manaka, Hisatsugu Ohori, Tatsuro Yamaguchi, Tamotsu Sagawa, Masahito Kotaka, Yutaro Kubota, Takashi Sekikawa, Masato Nakamura, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii, Akihito Tsuji

总体人群未见显著生存差异；左半RAS/BRAF野生型亚组的PFS结果属探索性，OS未达显著。

 35

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers

Julian R. Buissant des Amorie, Joris H. Hageman, Sascha R. Brunner, Suzanne E. M. van der Horst, Maria C. Puschhof, Arne van Hoeck, Inge van Lierop, Sjors Middelkamp, Lisa van der Schee, Sven van Kempen, Folkert Morsink, Robin Geene, Sander Mertens, David S. Cavigelli, Ingrid Verlaan-Klink, Lianne J. Kraaier, Jorieke Salij, Renate Bezemer, Onno Kranenburg, Miangela M. Laclé, Leon M. G. Moons, Hugo J. G. Snippert

早期肿瘤侵袭前沿出现胎儿样细胞状态，共培养实验支持局部微环境参与诱导。

 36

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

Qingwen Jiang, Manisha S. Raghavan, Aileen M. Rodriguez, Morgan Lallo, Cyrus L. Tam, Saskia Hartner, Britney Forsyth, Ahmed Mahmoud, Fabian Zincke, Huiyong Zhao, Andrew Moorman, Sasha Balkaran, Kathleen Luckett, Jura Pintar, Yevgeniy Romin, Eric Chan, Anthony Santella, Bernadette Mödl, Farheen Shah, Ilyes Baali, Michael G. Kharas, Elisa de Stanchina, Nil Urganci, Jinru Shia, Dana Pe’er, Francisco Sanchez-Vega, Richard Koche, Quaid Morris, Joseph M. Chan, Karuna Ganesh

ZFP36L2参与应激RNA清除；缺失影响再生与早期转移定植，幸存癌细胞仍可沿其他路径生长。